"Examine the patient and enter in all observed conditions. Then I will calculate the most probable disease."

The RONI (Rapid Operation Networked Intelligence) terminal is an intelligent computer mass-produced by the Portland government, designed to help diagnosticians. RONI holds a vast database of previous diseases that have occurred in history, and thus can help a diagnostician deduce the disease based on symptoms identified. In addition to this, the computer is also capable of contacting various places around the hospital to set up tests, be it for ultrasound, CT scans, or scintigraphy reports. RONI has a female voice.

Across Gabriel Cunningham's scenario, as the player identifies the patient's symptoms, RONI will record them and, when enough symptoms have been identified, bring up a list of possible diseases once the player consults it. Viewing a disease in detail will bring up a text describing its symptoms and causes, and dragging and dropping available symptoms into the text box will attempt to match the symptoms with the description.

RONI has a few roles outside the Diagnosis missions - it introduces a first-time player to the many ways to navigate the menu, along with informing the player about new changes to the menu, like locked scenarios, or the unlocking of several gameplay features like Doctor Medals. RONI also plays the bonus audio scenes after the game is completed.

RONI has been known to (badly) entertain Dr. Cunningham. In the second diagnosis episode, RONI and Gabe were playing cards, and RONI itself had stated that it had won 298 games out of 298 games. It was then revealed that RONI can perform a quadrillion instructions per second, or having the capability of a 1 THz processor.

RONI has also been shown to be able to update her system and data at the point of becoming more and more human because of Gabriel's attitude. She has been shown to develop humanity and to (humorously) introduce the option "To hell with that!" inside her system. She applied the "To hell with that!" algorithm to spontaneously search a past clinical case of Wermer syndrome during Joshua's diagnosis.